Súmula de disciplina


Disciplina BMB5785
Fisiologia Celular da Glândula Pineal

Área de Concentração: 42137


Criação: 12/12/2001


Ativação: 07/03/2002


Nr. de Créditos: 6


Carga Horária:

Desativação:


Teórica 
(por semana)
Prática 
(por semana)
Estudos 
(por semana)
Duração
Total
8
4
6
5 semanas
90 horas


Docente responsável:  Jose Cipolla Neto 

Solange Castro Afeche



Objetivo:


O Objetivo deste curso e discutir todos os aspectos fisiológicos celulares envolvidos na biossíntese de melatonina pelos pinealócitos.


Justificativa:


Justifica-se uma discussão aprofundada deste tema não só pela necessidade de o fisiologista estar informado sobre este assunto, mas, também, pelas características de modelo experimental para estudos fisilógicos celulares que a glândula possa vir a ter.


Conteúdo:


Introdução geral ao estudo da glândula pineal. Controle neuro-endócrino do metabolismo da glândula pineal. Neurotransmissores envolvidos na biossíntese de melatonina: aspectos histoquímicos, farmacológicos, bioquímicos e fisiológicos. Receptores celulares envolvidos no controle da biossíntese de melatonina pelos pinealocitos. Mecanismos de transdução de membrana envolvidos no controle do metabolismo dos pinealocitos: sistema proteina G e adenilciclase e guanilato ciclase; sistemas das fosfolipases A e C. Mecanismos intracelulares de transdução no controle da produção de melatonina pelos pinealocitos: AMP e GMP ciclicos, proteina quinase C, diacilglicocerol, cálcio e prostaglandinas. Mecanismos de controle da arilalquilamina N-acetiltransferase, enzima-chave na biossíntese de melatonina pelos pinealócitos.


Bibliografia:


1. Schaad, N.C., Parfitt. A., Russell, J.T., Schaffiner, A.E., Korf, H.W. and Klein, D.C. Single-cell [Ca2+]i analysis and biochemical characterization of pinealocytes immobilized with novel attachment peptide preparation. Brain Res. 614:251-256,1993 2. White, B.H. and Klein. D.C. Developmental appearance of pineal adrenergic guanosine 3', 5'-monophos hate response is determined by a process down-stream from elevation of intracellular Ca2+: Possible involvement of a diffusible factor. Endocrinology. 132:1026-1034, 1993 3. Yu, L., Schaad, N.C. and Klein, D.C. Calcium potentiates cyclic AMP stimulation of pineal arylarkylamine N-acetyltransferase. J. Neurochem. 60:1436-1443, 1993. 4. Babila, T., Schaad, N.C., Simonds, W.F., Shinohara, T. and Klein, D.C. Development of MEKA (phosducin), G beta, G gamma and S-antigen in the rat pineal gland and retina. Brain Res. 585:141-148, 1992. 5. Babila, T., Chaad, N.C. and Klein, D.C. Rat pineal Gsa, Gia and Goa: relative abundance and development. Brain Res. 572:232-235, 1992. 6. Babila, T. and Klein. D.C. Stimulus deprivation increases pineal Gs alpha and G beta J. Neurochem. 59:1356-1362, 1992. 7. Ho, A.K., Cheng, J. and Girard, M. Differential effects of intracellular calcium elevatin agents on adrenergic-stimulated cyclic nucleotide and melatonin synthesis in rat pinealocytes. Can. J. Physiol. Pharmacol. 70:1254-1260, 1992. 8. Ho, A.K. and Chik, C.L. Inhibitors of Na(+) - H+ exchange block stimulus-provoked pineal melatonin synthesis. Am. J. Physiol. 263:E481-E488, 1992. 9. Ho, A.K., O'Brien, L., Girard, M. and Chik, C.L. Intracellular pH on protein kinase C and ionomycin potentiation of isoproterenol-stimulated cyclic AMP and cyclic GMP production in rat pinealocytes. J. Neurochem. 59:2304-2310, 1992. 10. Klein, D.C., Schaad, N.L., Namboordiri, M.A., Yu, L. and Weller, J.L. Regulation of pineal serotonin N-acetyltransferase activity. Biochem. Soc. Trans. 20:299-304, 1992. 11. Schaad, N.C. and Klein, D.C. Characterization of alpha 2-adrenergic receptors on rat pinealocytes. Endocrinology. 130:2804-2810, 1992. 12. Weller, J.L. and Klein, D.C. The pineal adrenergic----cyclic GMP resoibse devekios twi weeks after the adrenergic----cyclic AMP response. Brain. Res. Dev. Brain. Res. 68:144-147,1992. 13. Cena, V., Halperin, J.I., Yeandle, S. and Klein, D.C., Norepinephrine stimulates potassium efflux from pinealocytes: evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3', 5'-monophosphate. Endocrinology. 128:559-569, 1991. 14. Chink, C.L.,, Young I. and Ho, A.K. Differential involvement of the arachidonic acid cascade on the alpha I-adrenergic potentiation of vasoactive intestina peptide-versus beta-adrenergic-stimulated cyclic AMP and cyclic GMP accumulation in rat pinealocytes. J. Neurochem. 57:1534-1539, 1991. 15.Chink, C.L. and Ho, A.K. See-saw signal processing: reciprocal effects of stimulus deprivation on vasoactive intestinal peptide-stimulated adenosine 3', 5'- pinealocytes. Endocrinology. 128:850-856, 1991. 16. Schaad, N.C., Shinohara, T., Abe, T. and Klein, D.C. Photoneural control fo the synthesis and phosphorylation of pineal MEKA (phosducin). Endocrinology. 129:3289-3298, 1991. 17. Sugden, D. Down-regulation of pinelocyte protein kinase C: effect on alpha 1-adrenergic potentiation of beta-adrenoceptor stimulation of cyclic AMP accumulation and induction of serotonin N-acetyltransferase activity. J. Neurochem. 58:216-221, 1991. 18. Ho, A.K. and Chink, C.L. Post-receptor mechanism in dual receptors regulation of second messengers in rat pineal gland. Prog. Clin. Biol. Res. 342:139-145,1990. 19. Reig, J.A., Yu, L. and Klein, D.C. Pineal transduction. Adrenergic----cyclic AMP-dependent phosphorylation of cytoplasmic 33-kDa protein (MEKA) which binds beta gamma-complex of transducin. J. Biol. Chem. 265:5816-5824, 1990. 20.Sugden, D. 5-Hydroxytryptamine amplifies beta-adrenergic stimulation of N-acetyltransferase activiry in rat pinealocytes. J. Neurochem. 55:1655-1658, 1990. 22. Sugden, D. Pertussis toxin does not inhibit alpha 1-adrenergic potentiation of beta-adrenergic stimulation of cyclic AMP accumulation in rat pinealocytes. Biochem. Biophys. Res. Commun. 168:871-877, 1990. 23. Aimoto, T., Rohde, B.H., Chiou, G.C. and Lauber, J.K. N-acetyltransferase activity and melatonin level in the eyes of glaucomatous chickens. J. Ocult. Pharmacol. 1:149-160, 1985. 24. Campa, A., Abdalla, D.S., Omoto, P. and Cipolla Neto, J. Superoxide dismutase and glutathione peroxidase activities in rat pineal gland. Biochem. Int. 27:407-415, 1992.


Contato: